Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27(Kip1)-dependent G1/S cell cycle arrest in conjunction with NF-κB activation

[Image: see text] 2-Methoxyestradiol (2-ME2) induces leukemia cells to undergo apoptosis in association with Bcl-2 inactivation but the mechanisms whereby Bcl-2 contributes to protection against programmed cell death in this context remain unclear. Here we showed that 2-ME2 inhibited the proliferati...

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Detaylı Bibliyografya
Asıl Yazarlar: Batsi, Christina, Markopoulou, Soultana, Kontargiris, Evangelos, Charalambous, Christiana, Thomas, Christoforos, Christoforidis, Savvas, Kanavaros, Panagiotis, Constantinou, Andreas I., Marcu, Kenneth B., Kolettas, Evangelos
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782607/
https://ncbi.nlm.nih.gov/pubmed/19447221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2009.03.017
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