Chronic NF-κB activation delays RasV12-induced premature senescence of human fibroblasts by suppressing the DNA damage checkpoint response

Normal cells divide for a limited number of generations, after which they enter a state of irreversible growth arrest termed replicative senescence. While replicative senescence is due to telomere erosion, normal human fibroblasts can undergo stress-induced senescence in response to oncogene activat...

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Detalhes bibliográficos
Main Authors: Batsi, Christina, Markopoulou, Soultana, Vartholomatos, George, Georgiou, Ioannis, Kanavaros, Panagiotis, Gorgoulis, Vassilis G., Marcu, Kenneth B., Kolettas, Evangelos
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765928/
https://ncbi.nlm.nih.gov/pubmed/19406145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2009.04.002
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