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Preferential Glutathione Conjugation of a Reverse Diol Epoxide Compared to a Bay Region Diol Epoxide of Phenanthrene in Human Hepatocytes: Relevance to Molecular Epidemiology Studies of Glutathione-S-Transferase Polymorphisms and Cancer

Bay region diol epoxides are recognized ultimate carcinogens of polycyclic aromatic hydrocarbons (PAH), and in vitro studies have demonstrated that they can be detoxified by conjugation with glutathione, leading to the widely investigated hypothesis that individuals with low activity forms of glutat...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Hecht, Stephen S., Berg, Jeannette Zinggeler, Hochalter, J. Bradley
פורמט: Artigo
שפה:Inglês
יצא לאור: 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765539/
https://ncbi.nlm.nih.gov/pubmed/19187038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx800315m
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