Kinetics of Oxidation of Benzphetamine by Compounds I of Cytochrome P450 2B4 and Its Mutants

Cytochromes P450 are ubiquitous heme-containing enzymes that catalyze a wide range of reactions in nature including many oxidation reactions. The active oxidant species in P450 enzymes are widely thought to be iron(IV)-oxo porphyrin radical cations, termed Compound I species, but these intermediates...

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Bibliografiske detaljer
Main Authors: Sheng, Xin, Zhang, Haoming, Im, Sang-Choul, Horner, John H., Waskell, Lucy, Hollenberg, Paul F., Newcomb, Martin
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765530/
https://ncbi.nlm.nih.gov/pubmed/19209859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja808982g
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