Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells

We examined in HepG2 cells whether glucose-induced changes in AMP-activated protein kinase (AMPK) activity could be mediated by SIRT1, an NAD-dependent histone/protein deacetylase that has been linked to the increase in longevity caused by caloric restriction. Incubation with 25 vs. 5 mM glucose for...

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Main Authors: Suchankova, Gabriela, Nelson, Lauren E., Gerhart-Hines, Zachary, Kelly, Meghan, Gauthier, Marie-Soleil, Saha, Asish K., Ido, Yasuo, Puigserver, Pere, Ruderman, Neil B.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764524/
https://ncbi.nlm.nih.gov/pubmed/19071085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2008.11.130
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