The Structure of the Dizinc Subclass B2 Metallo-β-Lactamase CphA Reveals that the Second Inhibitory Zinc Ion Binds in the Histidine Site

Bacteria can defend themselves against β-lactam antibiotics through the expression of class B β-lactamases, which cleave the β-lactam amide bond and render the molecule harmless. There are three subclasses of class B β-lactamases (B1, B2, and B3), all of which require Zn(2+) for activity and can bin...

Full description

Saved in:
Bibliographic Details
Main Authors: Bebrone, Carine, Delbrück, Heinrich, Kupper, Michaël B., Schlömer, Philipp, Willmann, Charlotte, Frère, Jean-Marie, Fischer, Rainer, Galleni, Moreno, Hoffmann, Kurt M. V.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764157/
https://ncbi.nlm.nih.gov/pubmed/19651913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00288-09
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items