The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA.

The Aeromonas hydrophila AE036 chromosome contains a cphA gene encoding a metallo-beta-lactamase which is highly active against carbapenem antibiotics such as imipenem. Here we show that the cphA gene product shares inhibitory similarities with a mammalian zinc peptidase, membrane dipeptidase (MDP;...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Keynan, S, Hooper, N M, Felici, A, Amicosante, G, Turner, A J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC162797/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7492120/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.39.7.1629
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