The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA.

The Aeromonas hydrophila AE036 chromosome contains a cphA gene encoding a metallo-beta-lactamase which is highly active against carbapenem antibiotics such as imipenem. Here we show that the cphA gene product shares inhibitory similarities with a mammalian zinc peptidase, membrane dipeptidase (MDP;...

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Bibliografische gegevens
Hoofdauteurs: Keynan, S, Hooper, N M, Felici, A, Amicosante, G, Turner, A J
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1995
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC162797/
https://ncbi.nlm.nih.gov/pubmed/7492120
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