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Antisense MDM2 Enhances E2F1-Induced Apoptosis and The Combination Sensitizes Androgen Dependent and Independent Prostate Cancer Cells To Radiation
We have previously demonstrated in separate studies that MDM2 knockdown via antisense-MDM2 (AS-MDM2) and E2F1 overexpression via adenoviral-mediated E2F1 (Ad-E2F1) sensitized prostate cancer cells to radiation. Because E2F1 and MDM2 affect apoptosis through both common and independent pathways, we h...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2763100/ https://ncbi.nlm.nih.gov/pubmed/19010821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-08-0102 |
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