C-terminal domain of SARS-CoV main protease can form a 3D domain-swapped dimer

SARS coronavirus main protease (M(pro)) plays an essential role in the extensive proteolytic processing of the viral polyproteins (pp1a and pp1ab), and it is an important target for anti-SARS drug development. We have reported that both the M(pro) C-terminal domain alone (M(pro)-C) and the N-finger...

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Bibliographic Details
Main Authors: Zhong, Nan, Zhang, Shengnan, Xue, Fei, Kang, Xue, Zou, Peng, Chen, Jiaxuan, Liang, Chao, Rao, Zihe, Jin, Changwen, Lou, Zhiyong, Xia, Bin
Format: Artigo
Language:Inglês
Published: Wiley Subscription Services, Inc., A Wiley Company 2009
Subjects:
Protein Structure Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2762595/
https://ncbi.nlm.nih.gov/pubmed/19319935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.76
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