Without Its N-Finger, the Main Protease of Severe Acute Respiratory Syndrome Coronavirus Can Form a Novel Dimer through Its C-Terminal Domain

The main protease (M(pro)) of severe acute respiratory syndrome coronavirus (SARS-CoV) plays an essential role in the extensive proteolytic processing of the viral polyproteins (pp1a and pp1ab), and it is an important target for anti-SARS drug development. It was found that SARS-CoV M(pro) exists in...

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Detalhes bibliográficos
Main Authors: Zhong, Nan, Zhang, Shengnan, Zou, Peng, Chen, Jiaxuan, Kang, Xue, Li, Zhe, Liang, Chao, Jin, Changwen, Xia, Bin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2293041/
https://ncbi.nlm.nih.gov/pubmed/18305043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02612-07
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