Three-dimensional domain swapping as a mechanism to lock the active conformation in a super-active octamer of SARS-CoV main protease

Proteolytic processing of viral polyproteins is indispensible for the lifecycle of coronaviruses. The main protease (M(pro)) of SARS-CoV is an attractive target for anti-SARS drug development as it is essential for the polyprotein processing. M(pro) is initially produced as part of viral polyprotein...

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Vydáno v:Protein Cell
Hlavní autoři: Zhang, Shengnan, Zhong, Nan, Xue, Fei, Kang, Xue, Ren, Xiaobai, Chen, Jiaxuan, Jin, Changwen, Lou, Zhiyong, Xia, Bin
Médium: Artigo
Jazyk:Inglês
Vydáno: Higher Education Press 2010
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4875095/
https://ncbi.nlm.nih.gov/pubmed/21203949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-010-0044-8
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