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Foldon unfolding mediates the interconversion between M(pro)-C monomer and 3D domain-swapped dimer
The C-terminal domain (M(pro)-C) of SARS-CoV main protease adopts two different fold topologies, a monomer and a 3D domain-swapped dimer. Here, we report that M(pro)-C can reversibly interconvert between these two topological states under physiological conditions. Although the swapped α(1)-helix is...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3443179/ https://ncbi.nlm.nih.gov/pubmed/22927388 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205241109 |
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