Transcriptional IL-15-Directed in vivo DC Targeting DNA Vaccine

DC engineered in vitro by DNA encoding OVAhsp70 and IL-15 up-regulated their expressions of CD80, CD86, CCR7 and IL-15Rα and promoted their productions of IL-6, IL-12 and TNF-α. Transcriptional IL-15-directed in vivo DC targeting DNA vaccine encoding OVAhsp70 elicited long-lasting Th1 and CTL respon...

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Bibliographic Details
Main Authors: Tian, S, Liu, Z, Donahue, C, Noh, HS, Falo, LD, You, Z
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2762487/
https://ncbi.nlm.nih.gov/pubmed/19727134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2009.110
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