Co-expression of IL-15 enhances anti-neuroblastoma effectivity of a tyrosine hydroxylase-directed DNA vaccination in mice

Long-term survival of high-risk neuroblastoma (NB) patients still remains under 50%. Here, we report the generation, in vitro characterization and anti-tumor effectivity of a new bicistronic xenogenic DNA vaccine encoding tyrosine hydroxylase (TH) that is highly expressed in NB tumors, and the immun...

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Vydáno v:PLoS One
Hlavní autoři: Marx, Madlen, Zumpe, Maxi, Troschke-Meurer, Sascha, Shah, Diana, Lode, Holger N., Siebert, Nikolai
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6242328/
https://ncbi.nlm.nih.gov/pubmed/30452438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0207320
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