Low CD4⁺/CD25⁺/CD127⁻ regulatory T cell- and high INF-γ levels are associated with improved survival of neuroblastoma patients treated with long-term infusion of ch14.18/CHO combined with interleukin-2

Immunotherapy with the anti-GD(2) antibody (Ab) ch14.18/CHO in combination with interleukin 2 (IL-2) has improved survival of high-risk neuroblastoma (NB) patients. Here, we report immunotherapy-related effects on circulating NK cells, regulatory T cells (T(regs)), granulocytes as well as on Ab-depe...

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Vydáno v:Oncoimmunology
Hlavní autoři: Troschke-Meurer, Sascha, Siebert, Nikolai, Marx, Madlen, Zumpe, Maxi, Ehlert, Karoline, Mutschlechner, Oliver, Loibner, Hans, Ladenstein, Ruth, Lode, Holger N.
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2019
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6844328/
https://ncbi.nlm.nih.gov/pubmed/31741754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2019.1661194
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