Impact of HACA on Immunomodulation and Treatment Toxicity Following ch14.18/CHO Long-Term Infusion with Interleukin-2: Results from a SIOPEN Phase 2 Trial

GD(2)-directed immunotherapies improve survival of high-risk neuroblastoma (NB) patients (pts). Treatment with chimeric anti-GD(2) antibodies (Ab), such as ch14.18, can induce development of human anti-chimeric Ab (HACA). Here, we report HACA effects on ch14.18/CHO pharmacokinetics, pharmacodynamics...

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Bibliographic Details
Published in:Cancers (Basel)
Main Authors: Siebert, Nikolai, Troschke-Meurer, Sascha, Marx, Madlen, Zumpe, Maxi, Ehlert, Karoline, Gray, Juliet, Garaventa, Alberto, Manzitti, Carla, Ash, Shifra, Klingebiel, Thomas, Beck, James, Castel, Victoria, Valteau-Couanet, Dominique, Loibner, Hans, Ladenstein, Ruth, Lode, Holger N.
Format: Artigo
Language:Inglês
Published: MDPI 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6210332/
https://ncbi.nlm.nih.gov/pubmed/30336605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers10100387
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