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Encephalitogenic T cells that stably express both T-bet and RORγt consistently produce IFNγ but have a spectrum of IL-17 profiles
Th1/Th17 cells, secreting both IFNγ and IL-17, are often associated with inflammatory pathology. We cloned and studied the cytokine phenotypes of MBP-specific, TCR-identical encephalitogenic CD4+ cells in relationship to Th1- and Th17-associated transcription factors T-bet and RORγt. IFNγ-producing...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2761534/ https://ncbi.nlm.nih.gov/pubmed/19692128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2009.07.007 |
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