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CD5 ENHANCES TH17 DIFFERENTIATION BY REGULATING IFN-γ RESPONSE AND RORγT LOCALIZATION
Mechanisms that modulate the generation of Th17 cells are incompletely understood. We report that the activation of CK2 by CD5 is essential for the efficient generation of Th17 cells in vitro and in vivo. The CD5-CK2 signaling pathway enhanced TCR induced activation of AKT and promoted the different...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3984608/ https://ncbi.nlm.nih.gov/pubmed/24356888 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201343998 |
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