CD5 ENHANCES TH17 DIFFERENTIATION BY REGULATING IFN-γ RESPONSE AND RORγT LOCALIZATION

Mechanisms that modulate the generation of Th17 cells are incompletely understood. We report that the activation of CK2 by CD5 is essential for the efficient generation of Th17 cells in vitro and in vivo. The CD5-CK2 signaling pathway enhanced TCR induced activation of AKT and promoted the different...

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Библиографические подробности
Главные авторы: McGuire, Donald J., Rowse, Amber L., Li, Hao, Peng, Binghao J., Sestero, Christine M., Cashman, Kevin S., De Sarno, Patrizia, Raman, Chander
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984608/
https://ncbi.nlm.nih.gov/pubmed/24356888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201343998
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