In the absence of writhe, DNA relieves torsional stress with localized, sequence-dependent structural failure to preserve B-form

To understand how underwinding and overwinding the DNA helix affects its structure, we simulated 19 independent DNA systems with fixed degrees of twist using molecular dynamics in a system that does not allow writhe. Underwinding DNA induced spontaneous, sequence-dependent base flipping and local de...

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Bibliographic Details
Main Authors: Randall, Graham L., Zechiedrich, Lynn, Pettitt, B. Montgomery
Format: Artigo
Language:Inglês
Published: Oxford University Press 2009
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2760789/
https://ncbi.nlm.nih.gov/pubmed/19586933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp556
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