Modeling Sequence Evolution in Acute HIV-1 Infection

We describe a mathematical model and Monte-Carlo (MC) simulation of viral evolution during acute infection. We consider both synchronous and asynchronous processes of viral infection of new target cells. The model enables an assessment of the expected sequence diversity in new HIV-1 infections origi...

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Main Authors: Lee, Ha Youn, Giorgi, Elena E., Keele, Brandon F., Gaschen, Brian, Athreya, Gayathri S., Salazar-Gonzalez, Jesus F., Pham, Kimmy T., Goepfert, Paul A., Kilby, J. Michael, Saag, Michael S., Delwart, Eric L., Busch, Michael P., Hahn, Beatrice H., Shaw, George M., Korber, Bette T., Bhattacharya, Tanmoy, Perelson, Alan S.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2760689/
https://ncbi.nlm.nih.gov/pubmed/19660475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtbi.2009.07.038
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