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Modeling sequence evolution in HIV-1 infection with recombination

Previously we proposed two simplified models of early HIV-1 evolution. Both showed that under a model of neutral evolution and exponential growth, the mean Hamming distance (HD) between genetic sequences grows linearly with time. In this paper we describe a more realistic continuous-time, age-depend...

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Detalhes bibliográficos
Main Authors: Giorgi, Elena E., Korber, Bette T., Perelson, Alan S., Bhattacharya, Tanmoy
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3667750/
https://ncbi.nlm.nih.gov/pubmed/23567647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtbi.2013.03.026
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