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The Influence of Double Bond Geometry in the Inhibition of Cyclooxygenases by Sulindac Derivatives
Sulindac sulfide is a benzylidene-indene that is a potent, time-dependent inhibitor of cyclooxygenases-1 and -2. Removal of the 2′-methyl group from the indene ring dramatically reduces time-dependent inhibition of both enzymes but also changes the geometry of the benzylidene double bond from Z to E...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2760071/ https://ncbi.nlm.nih.gov/pubmed/19427206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.04.078 |
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