The Influence of Double Bond Geometry in the Inhibition of Cyclooxygenases by Sulindac Derivatives

Sulindac sulfide is a benzylidene-indene that is a potent, time-dependent inhibitor of cyclooxygenases-1 and -2. Removal of the 2′-methyl group from the indene ring dramatically reduces time-dependent inhibition of both enzymes but also changes the geometry of the benzylidene double bond from Z to E...

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Main Authors: Walters, Matthew J., Blobaum, Anna L., Kingsley, Philip J., Felts, Andrew S., Sulikowski, Gary A., Marnett, Lawrence J.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2760071/
https://ncbi.nlm.nih.gov/pubmed/19427206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.04.078
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