Is Altered Expression of Hepatic Insulin-Related Genes in Growth Hormone Receptor Knockout Mice Due to GH Resistance or a Difference in Biological Life Spans?

Growth hormone receptor knockout (GHRKO) mice live about 40%–55% longer than their normal (N) littermates. Previous studies of 21-month-old GHRKO and N mice showed major alterations of the hepatic expression of genes involved in insulin signaling. Differences detected at this age may have been cause...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Panici, Jacob A., Wang, Feiya, Bonkowski, Michael S., Spong, Adam, Bartke, Andrzej, Pawlikowska, Ludmila, Kwok, Pui-Yan, Masternak, Michal M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2009
Pynciau:
Journal of Gerontology: Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759569/
https://ncbi.nlm.nih.gov/pubmed/19706698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glp111
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