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The Effects of Growth Hormone (GH) Treatment on GH and Insulin/IGF-1 Signaling in Long-Lived Ames Dwarf Mice

The disruption of the growth hormone (GH) axis in mice promotes insulin sensitivity and is strongly correlated with extended longevity. Ames dwarf (Prop1(df), df/df) mice are GH, prolactin (PRL), and thyrotropin (TSH) deficient and live approximately 50% longer than their normal siblings. To investi...

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Détails bibliographiques
Auteurs principaux: Masternak, Michal M., Panici, Jacob A., Wang, Feiya, Wang, Zhihui, Spong, Adam
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796883/
https://ncbi.nlm.nih.gov/pubmed/19906822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glp172
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