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Insulin Sensitivity as a Key Mediator of Growth Hormone Actions on Longevity

Reduced insulin sensitivity and glucose intolerance have been long suspected of having important involvement in aging. Here we report that in studies of calorie restriction (CR) effects in mutant (Prop1(df) and growth hormone receptor knockout [GHRKO]) and normal mice, insulin sensitivity was strong...

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Detalhes bibliográficos
Main Authors: Masternak, Michal M., Panici, Jacob A., Bonkowski, Michael S., Hughes, Larry F., Bartke, Andrzej
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667133/
https://ncbi.nlm.nih.gov/pubmed/19304940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glp024
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