Disruption of Growth Hormone Receptor Prevents Calorie Restriction from Improving Insulin Action and Longevity

Most mutations that delay aging and prolong lifespan in the mouse are related to somatotropic and/or insulin signaling. Calorie restriction (CR) is the only intervention that reliably increases mouse longevity. There is considerable phenotypic overlap between long-lived mutant mice and normal mice o...

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Detalhes bibliográficos
Main Authors: Bonkowski, Michael S., Dominici, Fernando P., Arum, Oge, Rocha, Juliana S., Al Regaiey, Khalid A., Westbrook, Reyhan, Spong, Adam, Panici, Jacob, Masternak, Michal M., Kopchick, John J., Bartke, Andrzej
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2639640/
https://ncbi.nlm.nih.gov/pubmed/19234595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004567
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