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GROWTH HORMONE ABOLISHES BENEFICIAL EFFECTS OF CALORIE RESTRICTION IN LONG-LIVED AMES DWARF MICE

Disruption of the growth hormone (GH) axis promotes longevity and delays aging. In contrast, GH over-expression may lead to accelerated aging and shorter life. Calorie restriction (CR) improves insulin sensitivity and may extend lifespan. Long-lived Ames dwarf (df/df) mice have additional extension...

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Bibliografske podrobnosti
izdano v:Exp Gerontol
Main Authors: Gesing, Adam, Al-Regaiey, Khalid A., Bartke, Andrzej, Masternak, Michal M.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252511/
https://ncbi.nlm.nih.gov/pubmed/25152388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2014.08.010
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