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Disruption of Growth Hormone Receptor Prevents Calorie Restriction from Improving Insulin Action and Longevity
Most mutations that delay aging and prolong lifespan in the mouse are related to somatotropic and/or insulin signaling. Calorie restriction (CR) is the only intervention that reliably increases mouse longevity. There is considerable phenotypic overlap between long-lived mutant mice and normal mice o...
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| Główni autorzy: | , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Public Library of Science
2009
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2639640/ https://ncbi.nlm.nih.gov/pubmed/19234595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004567 |
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