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Insulin Sensitivity as a Key Mediator of Growth Hormone Actions on Longevity

Reduced insulin sensitivity and glucose intolerance have been long suspected of having important involvement in aging. Here we report that in studies of calorie restriction (CR) effects in mutant (Prop1(df) and growth hormone receptor knockout [GHRKO]) and normal mice, insulin sensitivity was strong...

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Hlavní autoři: Masternak, Michal M., Panici, Jacob A., Bonkowski, Michael S., Hughes, Larry F., Bartke, Andrzej
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667133/
https://ncbi.nlm.nih.gov/pubmed/19304940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glp024
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