Affinity maturation and characterization of a human monoclonal antibody against HIV-1 gp41

The human D5 monoclonal antibody binds to the highly conserved hydrophobic pocket on the N-terminal heptad repeat (NHR) trimer of HIV-1 gp41 and exhibits modest yet relatively broad neutralization activity. Both binding and neutralization depend on residues in the complementarity determining regions...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Montgomery, Donna L, Wang, Ying-Jie, Hrin, Renee, Luftig, Micah, Su, Bin, Miller, Michael D, Wang, Fubao, Haytko, Peter, Huang, Lingyi, Vitelli, Salvatore, Condra, Jon, Liu, Xiaomei, Hampton, Richard, Carfi, Andrea, Pessi, Antonello, Bianchi, Elisabetta, Joyce, Joseph, Lloyd, Chris, Geleziunas, Romas, Bramhill, David, King, Vicki M, Finnefrock, Adam C, Strohl1, William, An, Zhiqiang
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Landes Bioscience 2009
Θέματα:
Reports
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759496/
https://ncbi.nlm.nih.gov/pubmed/20065653
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