Macrophage Antigen Complex-1 Mediates Reactive Microgliosis and Progressive Dopaminergic Neurodegeneration in the MPTP Model of Parkinson's Disease

Neuronal death is known to trigger reactive microgliosis. However, little is known regarding the manner by which microglia are activated by injured neurons and how microgliosis participates in neurodegeneration. In this study we delineate the critical role of macrophage Ag complex-1 (MAC1), a member...

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Detalhes bibliográficos
Main Authors: Hu, Xiaoming, Zhang, Dan, Pang, Hao, Caudle, W. Michael, Li, Yachen, Gao, Huiming, Liu, Yuxin, Qian, Li, Wilson, Belinda, Monte, Donato A. Di, Ali, Syed F., Zhang, Jing, Block, Michelle L., Hong, Jau-Shyong
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759089/
https://ncbi.nlm.nih.gov/pubmed/18981141
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