Macrophage Antigen Complex-1 Mediates Reactive Microgliosis and Progressive Dopaminergic Neurodegeneration in the MPTP Model of Parkinson's Disease

Neuronal death is known to trigger reactive microgliosis. However, little is known regarding the manner by which microglia are activated by injured neurons and how microgliosis participates in neurodegeneration. In this study we delineate the critical role of macrophage Ag complex-1 (MAC1), a member...

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Main Authors: Hu, Xiaoming, Zhang, Dan, Pang, Hao, Caudle, W. Michael, Li, Yachen, Gao, Huiming, Liu, Yuxin, Qian, Li, Wilson, Belinda, Monte, Donato A. Di, Ali, Syed F., Zhang, Jing, Block, Michelle L., Hong, Jau-Shyong
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759089/
https://ncbi.nlm.nih.gov/pubmed/18981141
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