miR-24 inhibits cell proliferation by suppressing expression of E2F2, MYC and other cell cycle regulatory genes by binding to “seedless” 3′UTR microRNA recognition elements

miR-24, up-regulated during terminal differentiation of multiple lineages, inhibits cell cycle progression. Antagonizing miR-24 restores post-mitotic cell proliferation and enhances fibroblast proliferation, while over-expressing miR-24 increases the G1 compartment. The 248 mRNAs down-regulated upon...

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Detalhes bibliográficos
Main Authors: Lal, Ashish, Navarro, Francisco, Maher, Christopher, Maliszewski, Laura E., Yan, Nan, O'Day, Elizabeth, Chowdhury, Dipanjan, Dykxhoorn, Derek M., Tsai, Perry, Hofman, Oliver, Becker, Kevin G., Gorospe, Myriam, Hide, Winston, Lieberman, Judy
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757794/
https://ncbi.nlm.nih.gov/pubmed/19748357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.08.020
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