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miR-24-mediated down-regulation of H2AX suppresses DNA repair in terminally differentiated blood cells
Terminally differentiated cells have reduced capacity to repair double strand breaks (DSB), but the molecular mechanism behind this down-regulation is unclear. Here we find that miR-24 is consistently up-regulated during post-mitotic differentiation of hematopoietic cell lines and regulates the hist...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2853019/ https://ncbi.nlm.nih.gov/pubmed/19377482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1589 |
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