miR-24-mediated down-regulation of H2AX suppresses DNA repair in terminally differentiated blood cells

Terminally differentiated cells have reduced capacity to repair double strand breaks (DSB), but the molecular mechanism behind this down-regulation is unclear. Here we find that miR-24 is consistently up-regulated during post-mitotic differentiation of hematopoietic cell lines and regulates the hist...

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Autori principali: Lal, Ashish, Pan, Yunfeng, Navarro, Francisco, Dykxhoorn, Derek M., Moreau, Lisa, Meire, Eti, Bentwich, Zvi, Lieberman, Judy, Chowdhury, Dipanjan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853019/
https://ncbi.nlm.nih.gov/pubmed/19377482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1589
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