A PP4-phosphatase complex dephosphorylates γ-H2AX generated during DNA replication

The histone H2A variant H2AX is rapidly phosphorylated in response to DNA double-stranded breaks to produce γ-H2AX. γ-H2AX stabilizes cell cycle checkpoint proteins and DNA repair factors at the break site. We previously found that the protein phosphatase PP2A is required to resolve γ-H2AX foci and...

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Main Authors: Chowdhury, Dipanjan, Xu, Xingzhi, Zhong, Xueyan, Ahmed, Fariyal, Zhong, Jianing, Liao, Ji, Dykxhoorn, Derek M., Weinstock, David M., Pfeifer, Gerd P., Lieberman, Judy
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242369/
https://ncbi.nlm.nih.gov/pubmed/18614045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.05.016
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