A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination

Double-stranded DNA breaks (DSBs) induce a phosphorylation-mediated signaling cascade, but the role of phosphatases in this pathway remains unclear. Here we show that human protein phosphatase 4 (PP4) dephosphorylates replication protein A (RPA) subunit RPA2, regulating its role in the DSB response....

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Hlavní autoři: Lee, Dong-Hyun, Pan, Yunfeng, Kanner, Shlomo, Sung, Patrick, Borowiec, James A, Chowdhury, Dipanjan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057140/
https://ncbi.nlm.nih.gov/pubmed/20154705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1769
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