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A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination
Double-stranded DNA breaks (DSBs) induce a phosphorylation-mediated signaling cascade, but the role of phosphatases in this pathway remains unclear. Here we show that human protein phosphatase 4 (PP4) dephosphorylates replication protein A (RPA) subunit RPA2, regulating its role in the DSB response....
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3057140/ https://ncbi.nlm.nih.gov/pubmed/20154705 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1769 |
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