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In Vivo Investigation of the Roles of FdmM and FdmM1 in Fredericamycin Biosynthesis Unveiling a New Family of Oxygenases

Fredericamycin (FDM) A, a highly oxidized aromatic pentadecaketide natural product, exhibits potent cytotoxicity and has been studied as a new anticancer drug lead. The FDM biosynthetic gene cluster has been previously cloned from Streptomyces griseus ATCC 49344 and successfully expressed in the het...

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Bibliografiska uppgifter
Huvudupphovsmän: Chen, Yihua, Wendt-Pienkoski, Evelyn, Rajski, Scott R., Shen, Ben
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2009
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757177/
https://ncbi.nlm.nih.gov/pubmed/19620242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.014191
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