Functional Characterization of ttmM Unveils New Tautomycin Analogs and Insight into Tautomycin Biosynthesis and Activity

[Image: see text] The biosynthetic gene cluster for tautomycin (TTM), a potent protein phosphatase (PP) inhibitor has recently been characterized. Inactivation of ttmM, which encodes a putative C3′ hydroxylase, afforded mutant SB6005 which accumulated three new 3′-deshydroxy TTM analogs, supporting...

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Detaylı Bibliyografya
Asıl Yazarlar: Ju, Jianhua, Li, Wenli, Yuan, Qiuping, Peters, Noel R., Hoffmann, F. Michael, Rajski, Scott R., Osada, Hiroyuki, Shen, Ben
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2707755/
https://ncbi.nlm.nih.gov/pubmed/19281218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol900293j
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