Increased inflammatory gene expression in ABC transporter deficient macrophages: free cholesterol accumulation, increased signaling via Toll-like receptors and neutrophil infiltration of atherosclerotic lesions

BACKGROUND: Two macrophage ABC transporters, ABCA1 and ABCG1 have a major role in promoting cholesterol efflux from macrophages. Peritoneal macrophages deficient in ABCA1 and/or ABCG1 show enhanced expression of inflammatory and chemokine genes. This study was undertaken to elucidate the mechanisms...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Yvan-Charvet, Laurent, Welch, Carrie, Pagler, Tamara A., Ranalletta, Mollie, Lamkanfi, Mohamed, Han, Seongah, Ishibashi, Minako, Li, Rong, Wang, Nan, Tall, Alan R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756536/
https://ncbi.nlm.nih.gov/pubmed/18852364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.108.793869
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados