Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice

HDLs protect against the development of atherosclerosis, but the underlying mechanisms are poorly understood. HDL and its apolipoproteins can promote cholesterol efflux from macrophage foam cells via the ATP-binding cassette transporters ABCA1 and ABCG1. Experiments addressing the individual roles o...

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Autores principales: Yvan-Charvet, Laurent, Ranalletta, Mollie, Wang, Nan, Han, Seongah, Terasaka, Naoki, Li, Rong, Welch, Carrie, Tall, Alan R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2007
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2066200/
https://ncbi.nlm.nih.gov/pubmed/17992262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33372
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