mTOR/S6 Kinase Pathway Contributes to Astrocyte Survival during Ischemia

Neurons are highly dependent on astrocyte survival during brain damage. To identify genes involved in astrocyte function during ischemia, we performed mRNA differential display in astrocytes after oxygen and glucose deprivation (OGD). We detected a robust down-regulation of S6 kinase 1 (S6K1) mRNA t...

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Bibliografiske detaljer
Main Authors: Dolores Pastor, María, García-Yébenes, Isaac, Fradejas, Noelia, Pérez-Ortiz, José Manuel, Mora-Lee, Silvia, Tranque, Pedro, Moro, María Ángeles, Pende, Mario, Calvo, Soledad
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Mechanisms Of Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755931/
https://ncbi.nlm.nih.gov/pubmed/19535330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.033100
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