mTOR/S6 Kinase Pathway Contributes to Astrocyte Survival during Ischemia

Neurons are highly dependent on astrocyte survival during brain damage. To identify genes involved in astrocyte function during ischemia, we performed mRNA differential display in astrocytes after oxygen and glucose deprivation (OGD). We detected a robust down-regulation of S6 kinase 1 (S6K1) mRNA t...

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Detalhes bibliográficos
Main Authors: Dolores Pastor, María, García-Yébenes, Isaac, Fradejas, Noelia, Pérez-Ortiz, José Manuel, Mora-Lee, Silvia, Tranque, Pedro, Moro, María Ángeles, Pende, Mario, Calvo, Soledad
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms Of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755931/
https://ncbi.nlm.nih.gov/pubmed/19535330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.033100
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