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Torpedo Nuclease Rat1 Is Insufficient to Terminate RNA Polymerase II in Vitro

Termination of RNA polymerase (pol) II transcription in vivo requires the 5′-RNA exonuclease Rat1. It was proposed that Rat1 degrades RNA from the 5′-end that is created by transcript cleavage, catches up with elongating pol II, and acts like a Torpedo that removes pol II from DNA. Here we test the...

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Hlavní autoři: Dengl, Stefan, Cramer, Patrick
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755851/
https://ncbi.nlm.nih.gov/pubmed/19535338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.013847
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