A Tandem SH2 Domain in Transcription Elongation Factor Spt6 Binds the Phosphorylated RNA Polymerase II C-terminal Repeat Domain (CTD)

Spt6 is an essential transcription elongation factor and histone chaperone that binds the C-terminal repeat domain (CTD) of RNA polymerase II. We show here that Spt6 contains a tandem SH2 domain with a novel structure and CTD-binding mode. The tandem SH2 domain binds to a serine 2-phosphorylated CTD...

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Détails bibliographiques
Auteurs principaux: Sun, Mai, Larivière, Laurent, Dengl, Stefan, Mayer, Andreas, Cramer, Patrick
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2010
Sujets:
Gene Regulation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009887/
https://ncbi.nlm.nih.gov/pubmed/20926372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.144568
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