Reversibility of Epithelial-Mesenchymal Transition (EMT) Induced in Breast Cancer Cells by Activation of Urokinase Receptor-dependent Cell Signaling

Hypoxia induces expression of the urokinase receptor (uPAR) and activates uPAR-dependent cell signaling in cancer cells. This process promotes epithelial-mesenchymal transition (EMT). uPAR overexpression in cancer cells also promotes EMT. In this study, we tested whether uPAR may be targeted to reve...

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Hlavní autoři: Jo, Minji, Lester, Robin D., Montel, Valerie, Eastman, Boryana, Takimoto, Shinako, Gonias, Steven L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Mechanisms of Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755690/
https://ncbi.nlm.nih.gov/pubmed/19546228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.023960
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