A Transformation in the Mechanism by which the Urokinase Receptor Signals Provides a Selection Advantage for Estrogen Receptor-expressing Breast Cancer Cells in the Absence of Estrogen

Binding of urokinase-type plasminogen activator (uPA)() to its receptor, uPAR, in estrogen receptor-α (ERα) expressing breast cancer cells, transiently activates ERK downstream of FAK, Src family kinases, and H-Ras. Herein, we show that when uPAR is over-expressed, in two separate ERα-positive breas...

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Main Authors: Eastman, Boryana M., Jo, Minji, Webb, Drue L., Takimoto, Shinako, Gonias, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383391/
https://ncbi.nlm.nih.gov/pubmed/22617030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2012.05.011
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