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A Transformation in the Mechanism by which the Urokinase Receptor Signals Provides a Selection Advantage for Estrogen Receptor-expressing Breast Cancer Cells in the Absence of Estrogen
Binding of urokinase-type plasminogen activator (uPA)() to its receptor, uPAR, in estrogen receptor-α (ERα) expressing breast cancer cells, transiently activates ERK downstream of FAK, Src family kinases, and H-Ras. Herein, we show that when uPAR is over-expressed, in two separate ERα-positive breas...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3383391/ https://ncbi.nlm.nih.gov/pubmed/22617030 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2012.05.011 |
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