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Endoplasmic Reticulum-associated Degradation (ERAD) and Autophagy Cooperate to Degrade Polymerogenic Mutant Serpins

The serpinopathies are a family of diseases characterized by the accumulation of ordered polymers of mutant protein within the endoplasmic reticulum. They are a diverse group including α(1)-antitrypsin deficiency and the inherited dementia familial encephalopathy with neuroserpin inclusion bodies or...

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Bibliografske podrobnosti
Main Authors: Kroeger, Heike, Miranda, Elena, MacLeod, Ian, Pérez, Juan, Crowther, Damian C., Marciniak, Stefan J., Lomas, David A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755687/
https://ncbi.nlm.nih.gov/pubmed/19549782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.027102
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