Ubx4 Modulates Cdc48 Activity and Influences Degradation of Misfolded Proteins of the Endoplasmic Reticulum

Misfolded proteins of the secretory pathway are recognized in the endoplasmic reticulum (ER), retrotranslocated into the cytoplasm, and degraded by the ubiquitin-proteasome system. Right after retrotranslocation and polyubiquitination, they are extracted from the cytosolic side of the ER membrane th...

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Bibliographic Details
Main Authors: Alberts, Sven M., Sonntag, Caroline, Schäfer, Antje, Wolf, Dieter H.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713509/
https://ncbi.nlm.nih.gov/pubmed/19359248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809282200
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