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Functional Rescue of β(1)-Adrenoceptor Dimerization and Trafficking by Pharmacological Chaperones

Site-directed mutagenesis guided by evolutionary trace analysis revealed that substitution of V179 and W183 within a cluster of evolutionarily important residues on the surface of the fourth transmembrane domain of the β(1)-adrenergic receptor (β(1)AR) significantly reduced the propensity of the rec...

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Autori principali: Kobayashi, Hiroyuki, Ogawa, Koji, Yao, Rong, Lichtarge, Olivier, Bouvier, Michel
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755524/
https://ncbi.nlm.nih.gov/pubmed/19515093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0854.2009.00932.x
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